hrp0094p2-62 | Bone, growth plate and mineral metabolism | ESPE2021

Severe Hypophosphatemic Rickets due to Tumor-Induced Osteomalasia

Haliloglu Belma , Pehlivan Enes , Yılmaz Duygu , Turan Cift Hakan , Tasdelen Neslihan , Sav Aydın , Alan Selcuk Nalan , Turan Serap ,

Introduction: Hypophosphatemic rickets is usually due to genetic causes but in rare cases it can develop secondary to MAS, Fanconi syndrome, or oncogenic causes. Oncogenic osteomalacia, also called Tumor-Induced Osteomalacia (TIO), is a rare acquired paraneoplastic syndrome that develops as a result of excessive phosphate loss from renal tubules by FGF23 released from tumour tissue. In addition to the clinical features of rickets, gait disturbances, growth ret...